I'm sorry, but response to what, exactly? I'm really not sure what you are looking for in your question. Here is the full verse and a little more context:
Matthew 7:21-27 (NASB)
"Not everyone who says to Me, 'Lord, Lord,' will enter the kingdom of heaven, but he who does the will of My Father who is in heaven will enter. Many will say to Me on that day, 'Lord, Lord, did we not prophesy in Your name, and in Your name cast out demons, and in Your name perform many miracles?' And then I will declare to them, 'I never knew you; DEPART FROM ME, YOU WHO PRACTICE LAWLESSNESS.' Therefore everyone who hears these words of Mine and acts on them, may be compared to a wise man who built his house on the rock. And the rain fell, and the floods came, and the winds blew and slammed against that house; and yet it did not fall, for it had been founded on the rock. Everyone who hears these words of Mine and does not act on them, will be like a foolish man who built his house on the sand. The rain fell, and the floods came, and the winds blew and slammed against that house; and it fell--and great was its fall."
Jesus is stating that many people will ultimately stand before Him claiming to have been His devout followers. However, they had no relationship with Him -- He never knew them. He was not really their Lord. Therefore they were not really His followers. An example of this can be found in Acts 19:13-17, where some exorcists attempt to cast out devils in the name of Jesus. However, they are not of Christ's flock:
Acts 19:13-17 (NASB)
But also some of the Jewish exorcists, who went from place to place, attempted to name over those who had the evil spirits the name of the Lord Jesus, saying, "I adjure you by Jesus whom Paul preaches." Seven sons of one Sceva, a Jewish chief priest, were doing this. And the evil spirit answered and said to them, "I recognize Jesus, and I know about Paul, but who are you?" And the man, in whom was the evil spirit, leaped on them and subdued all of them and overpowered them, so that they fled out of that house naked and wounded. This became known to all, both Jews and Greeks, who lived in Ephesus; and fear fell upon them all and the name of the Lord Jesus was being magnified.
These are the kinds of people whom Jesus is speaking about. In this particular example, their exorcism failed, however, another great example of this type of person would be Judas Iscariot, who successfully cast out demons in the name of Christ (Mark 6:7-13), yet never actually believed that Jesus is the Bread of Life (John 6:64).
Jesus is not saying that everyone who calls Him "Lord" will be cast into the Lake of Fire. Rather, He is simply saying that there will be many who do call Him Lord ON JUDGMENT DAY who never actually followed Him as Lord. These people are defined by the word "hypocrites". Jesus is here casting hypocrites from Him.
Another great verse relating to this is Luke 6:46 (NASB):
"Why do you call Me, 'Lord, Lord,' and do not do what I say?"
Here, Jesus is talking to the same types of people He is referring to in Matthew 7.
Hopefully this clears up your question, even though I am not really sure what your question is. I believe you asked this same question before, worded differently, and I answered it already, but I was never completely sure what you were referring to (and still am not).
I simply don't see how there is any way to read this as though "if you call Christ 'Lord', then you will go to hell", as I am pretty sure the questioner is intimating. Jesus says clearly that "Not everyone who says to Me, 'Lord, Lord,' will enter the kingdom of heaven", and therefore we understand that only SOME who say to Him 'Lord, Lord,' will enter the kingdom of heaven. Specifically, those who know Him intimately, trust Him as Lord, and obey Him as Lord. He says "everyone who hears these words of Mine and acts on them, may be compared to a wise man". If we obey Him as Lord, He says we are wise.
Christ will cast those who do not have an intimate relationship with Him into hell, even though they pretended to be His right-hand men.
Hopefully this clears up any misconceptions you may have had. Please try to be more clear in your questions so that I know more properly how to address them. Simply quoting a verse and asking me to respond doesn't tell me much about where the problem with the verse is in your mind.
I agree that he's talking about hypocritical behavior here but the focus is NOT on who did or did not have a relationship with him. He explicitly says "Depart from me, you who practice lawlessness." This is about actions/deeds not conforming to God's will, not about faith in Jesus as a Messiah.
Imagine God as a potter (Rom 9-19-21). God prepares each of us for the blessed life He has decided to give us. For some of us, our life on this earth is all the life God will bless us with. For others, God has chosen them to be adopted as sons.
I realize this understanding also means that there are people who are predestined to NOT "be saved". If I was one of those, I surely might be angry at God or disbelieve in His existence.
The only response I can give to this is, "The Lord gives and the Lord takes away. Blessed be the name of the Lord."